What is A-PRP® / PRP™?
A-PRP®/ PRP™ is the patient’s platelet concentrate prepared with RegenKit®The physician draws a small amount of venous blood and isolates the red cells from a platelet concentrate, embedded in its own plasma. The entire process takes less then 10 minutes.As A-PRP® is processed from the patients own blood, there is no risk of allergy or rejection with this treatment.
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A-PRP® / PRP™ Components
Platelets are key factors in hard and soft tissue repair mechanisms. They provide the essential growth factors FGF, PDGF, TGF-ß, EGF, VEGF, IGF that are involved in stem cell migration, differentiation and proliferation. The stimulation of fibroblasts and endothelial cells induces new extracellular matrix deposition and neo-vascularization.
Plasma is essential for cell survival as it contains nutrients, vitamins, hormones, electrolytes and proteins. Proteins are key molecules for the coagulation process and the formation of the fibrin polymer that will serve as a scaffold for cell migration, differentiation and proliferation.
Optimal Platelet Concentration
The Regen™ BCT (Blood Cell Therapy) tube prepares 4 to 5ml of autologous platelet rich plasma with a platelet recovery superior to 80% and a concentration factor of 1.6-fold. Although the system is technically capable of producing significantly higher platelet concentrations, it is not what research shows to be beneficial for clinical use. More and more studies demonstrate that concentrations of platelets 1 to 3 times over the baseline show more robust healing rates than those with concentrations of 3 to 8 times the baseline1.
Some studies even showed that too high platelet concentrations may actually have negative effects. In a in vivo study2 it was shown that highly concentrated platelet preparations had an inhibitory influence on osteoblast activity, probably due to unwanted inhibitory and cytotoxic effects of growth factors at such high concentrations. Similarly an in vitro study3, demonstrated that platelet concentration over 2.5-fold, resulted in a reduction in proliferation and a suboptimal effect on osteoblast function.
White Blood Cells in Tissue Regeneration
White blood cells are strongly reduced (> 85% depletion) in Regen BCT A-PRP®.
The role of white blood cells (WBC) in healing is controversially discussed among physicians. To address this concern scientifically, WBC subsets, granulocytes and mononuclear cells, need to be looked at individually. Granulocytes, and more specifically neutrophils, are the front-line defenders against invading pathogens and are associated with the inflammatory response. They release a large variety of highly active antimicrobial substances and proteases. Uncontrolled release of these factors can cause severe damage to the tissue, delay healing rates and increase the risk of scarring4. Thanks to the RegenKit BCT technology more than 96% of the granulocytes are removed from A-PRP®.
The few white blood cells still present in A-PRP® are mostly mononuclear cells (lymphocytes and monocytes). These two cell types are also involved in the immune response but have been shown to support the healing process5,6.
CELLULAR MATRIX™ PRP – PLASMOTHERAPY
PRP CELLULAR MATRIX ™ IS AN INNOVATIVE PATENTED METHOD BY REGENLAB (SWITZERLAND), WHICH ALLOWS YOU TO OBTAIN A BALANCED COMBINATION OF HYALURONIC ACID IN ONE TUBE, OBTAINED BY APPLYING MICROBIOLOGICAL FERMENTING METHOD AND AUTOLOGOUS PLATELET ENRICHED PLASMA (A-PRP).
Main advantage of this technology is a combination of deep revitalization and lifting:
hyaluronic acid produces the revitalization and skin moisturizing effect;platelet enriched blood plasma (A-PRP) stimulates skin regeneration at the cellular level, activates the new collagen response and improves circulation of blood;
These two components are treating simultaneously, mutually intensifying each other. This is why a synergistic effect is achieved.
CELLULAR MATRIX™ TEST GLASS
Blood collection tubes are consisting 2 ml of non-reticulated hyaluronic acid placed in Cellular Matrix™ volume of 2,0 ml without cross bonds (1550 kDa); concentration is 20 mg/ml (40 mg in each tube).
Hyaluronic acid in the tube prolongs the duration of immune system cells activity (thrombocytes) at injection site.
Clinical effect of combined treatment with plasma (А-PRP) RegenLab and hyaluronic acid in a single tube is much more signified in comparison with separate treatment with mentioned components, which is very important to achieve the simultaneous volumising and regenerating effect.
HYALURONIC ACID IN CELLULAR MATRIX™
It is not recommended to combine hyaluronic acid and platelet enriched plasma in one matrass under conditions of a beauty parlour and make an injection for patients. In case of contact of thrombocytes with acid environment of hyaluronic acid, they are being destroyed decreasing the effect of procedure itself.
RegenLab laboratory experts achieved the PH7 level of hyaluronic acid acidity in CELLULAR MATRIX™ tube, so the thrombocytes are not being destroyed in contact with this environment; conversely, the optimal “life environment” for cell expansion is achieved and the effect from this procedure is only enhanced.
Only non-stabilized unpreserved hyaluronic acid is used in CELLULAR MATRIX™ technology.
CELLULAR MATRIX™ – MECHANISM OF ACTION
CELLULAR MATRIX™ ensures the period of activity of thrombocytes and elution of growth factors in skin by creation of “comfort zone” for cells from hyaluronic acid “network” inside which the thrombocytes are spreading.
The lattice of hyaluronic acid is quickly covered by fibroblasts – cells producing the components of extracellular matrix, ensuring the constant resurfacing of skin in conjunction with consistent hydration (moisturizing) of deep skin layers.
Due to the optimal “life environment” created by the hyaluronic acid, growth factors are longer active with more signified effect in tissues, stimulating the regeneration of skin: increase of new collagen response of III and IV types, prolonged hydration (moisturizing), angiogenesis (neovascularisation).
DIRECTIONS FOR CELLULAR MATRIX™ PROCEDURE
Simultaneous effect of deep, long-lasting and stable hydration, rejuvenation and modulation of lineaments allowing to avoid the whole complex of age-related skin changes problems:
skin dryness and laxity;wrinkles and creases (including nasolabial fold);irregularities of skin colour and micro relief;losing of lower face sharp contours;skin photoageing, stress aftereffects.
CELLULAR MATRIX™ PROCEDURE IS THE BEST FIT FOR
Procedure is effective for ageing skin, losing tone and against wrinkles. Injections are used for the face zone (rejuvenation and styling of temples, mid face and lower face), for the neck and décolleté zone.
For the body skin around bikini zone, internal surface of forearms, stomach, wrists, elbows, knees.
RESULTS OF CELLULAR MATRIX™ PROCEDURE
The following complex effect is achieved as the result of CELLULAR MATRIX™ injection procedures:
skin stiffness is increased;wrinkles and creases become less visible and disappear;skin is tightening, becoming firm and compact;skin tone is levelling and increasing;deep moisturising of skin;face sharp contours are increasing.
CELLULAR MATRIX™ PROCEDURE CONTRA-INDICATIONS
blood diseases;nasty forms of pancreatic diabetes;acute infectious diseases;oncology diseases;severe intoxication;pregnancy and lactation.
CELLULAR MATRIX™ PROCEDURE COURSE
For the best effect of skin tightening and rejuvenation a course of 3 CELLULAR MATRIX™ procedures is recommended spaced a month apart.
After that 3-4 annual procedures are enough to keep the reached effect.